#cell
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Scientists reverse liver cell aging and cut Alzheimer’s-linked protein in half
A surprising discovery suggests that rejuvenating the liver could help protect against Alzheimer’s disease and heart disease. USC researchers found that an experimental drug restored aging liver cells in rats, cutting levels of an Alzheimer’s-linked protein in half and bringing bad cholesterol down to youthful levels. The treatment also revived a previously unknown communication system that helps liver cells remove harmful substances from the bloodstream.
ScienceDaily · EN
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小鼠研究发现骨骼在运动中会释放延缓衰老和延寿的蛋白质
骨骼塑造着体型，也影响着衰老。根据发表在《Cell Metabolism》期刊上的一项研究，小鼠实验发现骨骼在机械应力下——锻炼或其它身体活动中间发生的推、拉、扭转等——会触发骨骼释放名为骨细胞（osteocytes）的力感知细胞，促使其分泌出有抗衰老作用的化学物质。研究团队甚至通过轻微挤压小鼠腿骨，成功使其寿命延长了近 3 个月，相当于人类寿命延长了约 9 年。研究负责人、南方医科大学的 Xiaochun Bai 表示，骨骼并非仅是一个被动的支撑框架；它是一个活跃的、能对机械力做出反应的器官，在很大程度上决定了全身衰老的进程。研究人员尚未在人体中验证这一效应，因此它未必适用于人类。过去几十年的研究表明，体育锻炼及其它形式的身体活动与更长的寿命密切相关，这一现象背后的机制尚不清楚。Bai 指出大多数科学家此前都在肌肉中寻找线索，却忽略了骨骼。
Solidot · ZH
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Author Correction: mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis
Nature, Published online: 02 November 2026; doi:10.1038/s41586-026-11350-5 Author Correction: mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis
Nature News · EN