Scientists reveal how cosignaling receptors dually regulate T cell activation via phase separation
Kaynak: Phys.org ·
Previous studies have shown that upon antigen stimulation, the T cell receptor (TCR) undergoes phase separation with the kinase Lck to mediate rapid T cell activation. However, the manner in which costimulating receptors regulate this process has remained unclear.
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Scientists reveal how cosignaling receptors dually regulate T cell activation via phase separation, Makale kategorisinde yer alan ve Phys.org üzerinden sunulan bir keşiftir. Previous studies have shown that upon antigen stimulation, the T cell receptor (TCR) undergoes phase separation with the kinase Lck to mediate rapid T cell activation. However, the
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